Крок 2 · Фармація, промислова фармація 2009 · Англійська

Analysis of an extract by chromatographic method revealed presence of phenyl prapanolamine. It is the metabolite of the following alkaloid:

During local anaesthetization novocai-ne solution is usually compounded with solution of adrenaline hydrochloride. What is the purpose of this action?

A 32-year-old patient takes antituberculous drugs. Some time later he has noticed that his urine turned orange. What preparation is the most likely cause of this phenomenon?

6 months after treatment a patient with coronary heart disease developed tolerance to the nitrates with prolonged action. What drug with nitrate-similar effect should be recommended in this case?

A 52-year-old patient was diagnosed with systemic amebiasis accompanied by bowels, liver and lungs affection. What preparation should be administered?

A 33-year-old woman who has been treated for chronic polyarthritis for a long time complains about arterial pressure rise, change of adipose tissue distribution, menstrual cycle disorder. What preparati- on has she taken?

A pharmaceutist made a tincture of althaea root. What is the proportion of herbal crude drug and extractant?

A pharmaceutical enterprise widely applies technical and technological media of information use in order to increase efficiency of managing productive and administrative activity of an organization, to enhance labour productivity, to improve methods of planning and regulating management processes. All this is realized by means of:

Marketing research of certain pharmaceutical groups involves collection and analysis of primary information. This is the following type of marketing research:

An analytical laboratory carries out quantitative analysis of sodium citrate by method of ionexchanging chromatography on a cationite. What titrated solution is to be used for the following titration of generated citric acid?

A pharmaceutist prepared an oil emulsion containing zinc oxide. Specify the rational method of substance incorporation:

A pharmaceutist made a tincture of Adonis herb. A peculiarity of its preparation is that the active substances are derived in:

Preparations made of ginseng roots have tonic and adaptogenic properties, improve mental and physical performance. If the ginseng tincture cannot be found in a pharmacy, it can be substituted by the analogous preparations made of the following raw material:

Balance is a part of financial accounting of pharmacies. What index is reflected in the assets of the balance sheet?

The market is characterized by the following conditions: a big number of salespersons and customers who don’t make any influence upon the level of current prices; availability of uniform and interchangeable competing products; lack of price restrictions. What type of market is it?

If the internal surface of buckthorn rind is moistened with 5% alkaline solution, it becomes cherry-red colouring. This is the evidence of presence of the following substance:

A pharmacy technologist received an ointment formulation: Rp.: Unguentum Resorcini 1,5% -10,0 Da. Signa. To be applied on the affected skin areas. The pharmaceutist incorporated dry medical substance into the ointment by the following way:

A pharmacy analyst can verify presence of iron cation (II) in a drug formulation by means of the following solution:

An advance holder (accountant) received money from the cash fund of an enterprise for purchase of office accessories. After the cash advance the advance holder must submit the statement of application of funds no later than:

Choose an antiseptic from the group of halogen containing drugs that can be included into the first-aid kit for a child going to a summer camp:

A pharmacy received a new-generation nonsteroid anti-inflammatory drug 'meloxicam'that mainly blocks cyclooxygenase-2. What advantages does this preparation have in comparison with other nonsteroid anti-inflammatory drugs?

Leaves of belladonna, henbane and datura containing tropane alkaloids must be stored according to the following list requirements:

A patient suffering from essential hypertension has increased concentration of renin in blood plasma. Which pharmacological group should be preferred for this patient treatment?

A patient suffering from stomach ulcer was prescribed almagel. Which of its pharmacological properties is intended for treatment of this pathology?

One of the ways to derive essential oil is enfleurage, or maceration. Essential oil can be derived by enfleurage from the following herbal raw material:

A pharmaceutist and a pharmacy manager were involved into the labour dispute about carry over of vacation time. The pharmaceutist applied to the council of conciliation. The council should consider his application within the following period:

All the medications require special storage conditions according to their physical and physicochemical properties. Ampouled solution of sodium adenosine triphosphate (ATP) should be stored under the following temperature:

Quality control of tablets produced at a pharmaceutical enterprise involves quantitative determination of such subsidiary substances as talc and aerosil. What method is applied for such determination?

A 52-year-old patient had myocardial infarction and was discharged from the hospital after the stationery treatment. What daily dose of acetylsalicylic acid should be administered in order to prevent thrombosis?

An analyst of a pharmaceutical storehouse received the substance of hydrogen peroxide for analysis. Quantitative determination of this drug should be performed by permanganatometric method. According to the analytical normative document, titration should be carried out till the solution turns:

A patient suffering from ulcer disease was prescribed famotidine. What is the mechanism of its action?

Ophthalmic drops are produced on the base of concentrated riboflavin solution (1:5000). How much solution should be taken if the formulation says '0,001 of riboflavin'?

While producing phytopreparations and organotherapeutic preparations different kinds of dryers are used. What dryer would be the most effective for drying thermolabile compounds?

Choose an optimal antibacterial drug for the mycoplasmal pneumonia treatment:

An analytical laboratory received substance of citric acid for the analysis. According to the requirements of the Ukrainian State Pharmacopoeia, citric acid can be determined by method of:

According to the requirements of the Ukrainian State Pharmacopoeia, the amount of calcium gluconate can be determined by the chelatometric method. What solution should be used as a titrant?

Tannins have astringent effect and are used for treatment of colitis, enterocolitis, diarrhea. What herbal raw material contains a lot of tannins?

Anthracene derivatives of emodi-ne group exhibit purgative effect. What herbal raw material contains large quantity of anthracene derivatives of emodine group?

Codeine can be derived for medical purposes out of a plant alkaloid by means of semisynthetic method. Name this alkaloid:

Theory of management currently marks out four the most important approaches to the management. Choose the approach that is NOT USED in the theory of management:

Therapeutic department of a municipal hospital purchases medical products in a pharmacy. The wares will be dispensed from the stores department on presentation of the following document:

In order to determine the purity a drop of lavender essential oil was applied on a strip of filter paper and warmed up in the stream of warm air. Some time later the stain increased in diameter. What impurity substance was found in the lavender oil?

A doctor prescribed a patient 100 ml of tincture made out of 0,25 of Herba Thermopsidis. How much dried concentrated extract of Herba Thermopsidis should be weighed by a pharmaceutist?

A patient has ordered 50 g of zinc ointment. How much zinc and Vaseline should be weighed by a pharmaceutist?

A patient got an injection of 0,25% novocaine solution for the purpose of anaesthetization. Suddenly the patient has presented with red spots, intense sweating, tachycardia, bronchospasm, edema of nasal mucous membrane. What is the cause of this complication?

In Ukraine the out-patients are supplied with narcotic and psychotropic drugs only by prescription. Medicoprophylactic institutions receive prescription blanks (Form 3) from the following source:

Injection solutions of salts derived from weak acids and strong bases require stabilization. What stabilizers are used for these solutions?

100 ml of 0,9% sodium chloride solution were prepared according to the doctor’s prescription. What sterilization schedule is required for this solution?

During digitoxin therapy for chronic cardiac insufficiency, a patient developed signs of intoxication with this preparation. The patient was prescribed unithiol. What is the mechanism of unithiol action in case of intoxication with cardiac glycosides?

A pharmacy got a formulation of a mixture containing manzanita decoction and belladonna extract. What is the reason for incompatibility between these components?

The central district pharmacy functions in a district centre and supplies local population with drugs and medical products. What pharmaceutical institutions are allowed to settle accounts with the customers without a cash register by way of check issuing?

Method of gas-liquid chromatography is often applied for identification and quantitative determination of toxicologically meaningful substances. Substances can be placed into the chromatograph dispenser in the following aggregate states:

Examination of a patient who has been treated for rheumatoid arthritis for a long time revealed hyperglycemia. It might have been caused by the following drug:

A pharmaceutist was preparing an ointment with ricin oil and Vaseline but failed to get homogenous system. What is the most likely cause of incompatibility between these components?

A large and well-known company has granted a small independent firm the right to use its trademark and technology so that it could take advantage of authori- ty and customer trust to the well-known brand. Such concept is called:

A woman who has been treated for infiltrative focal tuberculosis for a long time complains of acute hearing impairment. Which of the following preparations might be the cause of such side effect?

A pharmaceutist revealed physical incompatibility caused by coagulation. This process takes place in a solution if the combination of the following substances is present:

A pharmaceutist made a medicinal preparation according to the following formulation: Rp.: Chloroformii Olei Helianthi Methylii salicylatis ana 10,0 M.D.S. For infriction. Specify the kind of disperse system:

Aerosol composition includes active substances, solvents and propellents. Which of the following substances is used as propellent?

A department producing sterile pharmaceutical forms needs a method of eye drops sterilization applicable for drugs derived from thermolabile substances. What is the optimal method of sterilization?

Accounting of pharmaceutical institutions includes control accounts of nine classes. What accounting units are represented in the accounts of the 4-6 classes?

A pharmaceutist revealed physical incompatibility in a recipe. Specify the combination of drug substances demonstrating eutectic when blended:

What drug may cause constipation in a patient undergoing combined therapy for arterial hypertension?

Management of a pharmaceutical company involves American and Japanese approaches. Choose a typical feature of American model of management:

Quantitative analysis of drugs containing primary aromatic amine can be performed by means of nitritometric method. Which of the following preparations can be determined by the nitritometric method without preliminary acid hydrolysis?

When filling the 'Inventory report', a pharmacy manager represented a number of business transactions in the receipts section of report. Such transactions include:

A patient suffering from neurosis accompanied by anxiety and fear development was prescribed diazepam. What pharmacological effect makes it possible to apply the drug for this disease treatment?

A hospital admitted a child with signs of poisoning with belladonna alkaloids. What drug should be applied as an antidote?

You are employed in a pharmaceutical storehouse. When adding newly received preparations to the computerized database, specify the pharmacological group of paracetamol:

A 34-year-old patient suffering from bronchitis was prescribed an antitussive drug of central action. What drug is it?

Continuous taking of a drug results in reduction of its efficiency. This phenomenon is called:

A patient was warned that taking the prescribed preparation might cause cough. What drug is it?

A pharmaceutist with over 8 years of service got a medical certificate in accordance with the established procedure. What is the size of temporary disability allowance the pharmaceutist is entitled to?

A pharmacy functions on the base of collective financial liability. The financial liability agreement may be re-executed in the following case:

A pharmacy sells drugs by retail. Omnopon relates to the following group of controlled drugs:

A pharmaceutical company 'Pharmasvet'has patented and produces now a new hypoglycemic preparation. The company markets this product directly through the own marketing departments, affiliated marketing companies, pharmacy network. Marketing policy of this pharmaceutical company can be characterized by the channel of the following level:

A patient with acute cardiac insufficiency and cardiac glycoside intolerance got an injection of dobutamine. What is the mechanism of its action?

A patient suffering from chronic cardiac insufficiency was prescribed a cardiac glycoside from the foxglove (Digitalis) group. What drug is it?

One of the methods of quantitative analysis of active substances in the raw material is the biological standardization. It can be applied with the following group of biologically active substances:

Lipophilic bases for suppositories include:

An expert of an analytical laboratory is determining Nitrofural. What quanti- tative titrimetric method can be applied?

A 52-year-old patient complains of having increased arterial pressure for a month. She has a 5year history of bronchial asthma. What group of hypotensive drugs should NOT be recommended this patient?

A pharmacy analyst is determining one of the following drugs by the nintri-tometric method. What drug is it?

A chemotoxicological laboratory received a biological material. A toxicologist carries out uncontrollable analysis aimed at detection of the following group of toxic substances:

Quality of injection solutions supplied in ampoules can be assessed according to different indices. How many ampoules should be checked while determining quality of sealing ( leaktightness of an ampoule)?

A chemical department produces alcohol solution of boric acid. What filters are used for filtration of this solution?

An 18-year-old patient was diagnosed with disseminated pulmonary tuberculosis. What drug will provide etiotropic pharmacotherapy?

At the end of each month accountant of a pharmacy calculates amount of realized price markup. Which index IS NOT USED for such calculation?

Suspensions as heterogenous systems can be characterized by kinetic and sedimentary instability. What substance is used for increasing suspension stability with hydrophobic substances?

A pharmacy analyst is determining adrenaline tartrate by method of acid-base titration in the anhydrous solvents. What indicator is to be used according to the requirements of the Ukrainian State Pharmacopoeia?

A patient has accidentally taken a barium-containing salt. All of the following salts have toxic effect upon the human organism EXCEPT for:

A mineralizate under examination contains precipitates of barium sulfate and plumbum sulfate. These salts can be separated by means of:

A pharmaceutical company 'Adonis'promotes its new products by means of advertisement that informs the customers about the product, highlights its advantages, typical features and properties. What kind of advertisement is it?

The founders are going to open a retail pharmacy. What way of business running is stipulated in this case?

While preparing decoctions in volume from 1000 to 3000 ml time of processing in boiling water bath should be:

A pharmacy analyst is measuring a drug by method of indirect bromatometry. Which of the following titrated solutions is to be used?

An expert of an analytical laboratory is determining Ca2+ in the substance of calcium pantothenate. Specify the method of analysis:

Styles of maize with stigmata containing fatty acids, vitamins, essential oils, saponins and other substances are used as:

Toxic substances can be isolated from the objects of biological origin by different methods. In case of poisoning with pesticides - derivatives of phosphoric acids -the following method is applied:

Dispersion degree of drug substances is of great importance for the preparation of ophtalmic ointments. What drug substance should be thoroughly triturated with sterile vaseline oil before incorporating it into the pharmacopoeia-recommended ointment base?

Financial accountability of pharmacies consists of separate account forms. Which form presents accounts payable for the goods purchased?

In Ukraine natural persons and small business entities are allowed to use the simplified tax system. What limit on the number of employees is established for such enterprises?

Fatty oil containing saturated fatty acids is used for atherosclerosis prevention. Specify the medicinal plant that is used for oil production:

A department of a pharmaceutical plant produces injection solutions. Ascorbic acid solution for injections relates to the following group of solutions:

A phytochemical department of a pharmaceutical factory produces biogenic stimulators out of different raw materials. Specify the plant-derived biogenic stimulators:

A pharmaceutist has prepared an ointment intended for application on the open wound surface. Such kind of ointment should meet the following additional requirement:

Powders represent an important group among the extemporal medicinal preparations. Which of the following components can be incorporated into a powder without preliminary grinding?

Medications in the storing rooms of a medicoprophylactic institution should be placed on the shelves, in the cases, refrigerators or on the pallets or rickers. Toxic medications should be kept in:

A storehouse received a batch of althaea roots. For its verification a drop of ammonia solution was applied upon the root section; the spot of section turned yellow. This is the evidence of presence of the following substance:

According to the requirements of the Ukrainian State Pharmacopoeia, a pharmacy analyst is determining procaine hydrochloride by nitritometric method. What indicator should be used for this purpose?

According to the requirements of the Ukrainian State Pharmacopoeia, a pharmacy analyst is determining fluorouracil by method of nonaqueous titration. What titrated solution is to be used?

According to the requirements of the Ukrainian State Pharmacopoeia, a pharmacy analyst is determining calcium gluconate by method of complexometric titration. What indicator is to be used?

According to the requirements of the Ukrainian State Pharmacopoeia, a certain drug is being measured by method of chelatometric titration. What drug is it?

An analytical laboratory carries out an analysis of ferrum sulphate heptohydrate according to the requirements of the Ukrainian State Pharmacopoeia. The test portion of the substance should be titrated with the following solution:

A patient suffering from arterial hypertension and chronic bronchitis suddenly presented with dry cough and dyspnea. Body temperature remained unchanged. It is known that the patient takes captopril. These symptoms can be explained by increased generation of:

A man came to a pharmacy and asked to recommend him a drug for treatment of allergic rhinitis that occurs in the period of linden flowering. What drug may be applied?

During the sensitifity test for benzylpenicillin a patient developed anaphylactic shock. The following preparation must be injected around the spot of antibiotic injection:

A pharmaceutist is preparing powders by the way of triturating one of the components with ethyl alcohol. Such technology of preparation is typical for the following substance:

An accountant is calculating financial performance of a pharmacy. What item will be represented in the liabilities of the accountingreport791 called 'Operational result'?

The equity capital of a pharmacy is 7500 UAH, the liabilities make 2500 UAH. According to the formula of balance calculation given in the Statement of Standard Accounting Practice 2 the amount of pharmacy assets will be as follows:

Novocaine metabolism in the organism results in generation of p-amino-benzoic acid. What metabolic process underlies this conversion?

A patient got poisoned with nitrites. Nitrite detection by means of azo dye reaction involves using such acid:

Fruits of holy thistle (Silybum) are used for production of a number of domestic and foreign hepatoprotective drugs. Factor of merit of this raw material is content of:

According to the pharmacopoeia requirements of liquid extract production, the extractant and the raw material should be taken in the following proportion:

A pharmacy got an order for powders containing ascorbic acid and sodium hydrocarbonate. What process takes place between the ingredients?

An analyst is measuring sodium benzoate in the anhydrous medium by the acidimetric method according to the requirements of the Ukrainian State Pharmacopoeia. What reagent had to be used as a solvent?

A pharmacy analyst is measuring mercury dichloride by method of indirect chelatometry. Excess of titrated solution of sodium edetate can be titrated by means of the following titrated solution:

Calcium lactate can be quantitatively determined by chelatometric method. According to the Ukrainian State Pharmacopoeia, the following substance should be used as indicator:

A pharmacy analyst of an analytical laboratory is studying procaine hydrochloride according to the requirements of the Ukrainian State Pharmacopoeia. What method is recommended by the Ukrainian State Pharmacopoeia for the quantitative analysis of this preparation?

A pharmacy got the following recipe: Rp.: Mucilaginis Amyli 50,0 Da. Signa. For the enema purposes. How much starch and distilled water did the pharmaceutist use in order to make this preparation?

Aerosol production involves usage of propellents relating to different groups. Choose the propellants that relate to the group of volatile organic solvents:

Which preparation from the group of laxative agents IS NOT to be administered in case of intoxication with CNS-inhibiting substances?

A patient with bronchial asthma was prescribed salbutamol that has led to relief of bronchospasm symptoms. This is associated with stimulation of:

A pharmacy analyst is going to take a part of his holiday in spring and a part in summer. Holiday dividing is allowed provided that its main part will be no less than:

TV periodically conducts campaigns for young people aimed at popularization of mechanical contraceptives (not indicating concrete trademarks). Such actions are a kind of the following marketing communication:

A biennial or perennial plant from the Apiaceae family has a blue-grey stem branching in its lower part. Its leaves are also blue-grey, finely dissected, with the ultimate filiform segments. The flowers are yellow, in compound umbels. Its fruit is used for production of 'dill water'. What plant is it?

Water for injections is derived from the drinking or distilled water. It can be either used freshly made or stored under the required temperature conditions. Water for injections is produced in the following premises:

Department of finished drug products of the pharmacy №1 got a prescription for nasal drops 'Farmazolin'intended for a 2,8-year-old child. This drug will be dispensed at the following price:

On the base of licorice root different drug dosage forms are produced, notably tablets, powders, syrups, teas. The only unused form is injection solution. Licorice roots exhibit haemolytic properties since they contain the following active substances:

A pharmaceutical factory produces camphor oil for topical application. What oil is to be used as a solvent?

A pharmaceutical enterprise produces ointments. What base is applied for production of sulfur ointment simple?

One of the accounting documents of a pharmacy is the balance sheet (Form 1) consisting of assets and liabilities. Name the elements of the asset of a pharmacy:

A 46-year-old patient suffering from chronic bronchitis came to a pharmacy. What expectorative drug may be recommended?

A 26-year-old pregnant woman (III trimester of pregnancy) complains about body temperature rise up to 39°C. What febrifuge may be recommended in this case?

Forensic toxicological analysis is often done for the metabolism products of toxic substances. Amino benzophenones are generated during biotrasformation of:

A 48-year-old patient was given an intravenous injection of prednisolone in order to arrest a severe attack of bronchial asthma. Prednisolone relates to the following group of hormonal drugs:

A patient who has been taking phenazepam for a month came to a pharmacy. He insisted on buying another two packs of this drug. According to the patient, he feels unwell without phenazepam. What is the mechanism of the developed side effect?

A patient suffering from allergic rhinitis was prescribed ephedrine in form of nasal drops. The patient has significantly benefited from nasal instillation, and this stimulated him to use the drug every 2 hours. But under these conditions the drug appeared to be ineffective. What is the most likely cause of this phenomenon?

Adjuvant substances in the production of tablets give the tableted mass all necessary technological properties, ensure dosage precision, mechanical strength and stability of tablets during their storage. What adjuvant substances facilitate disintegration or solution of the tablets in the organism?

In case of loss of license a pharmaceutist should address an application for a duplicate to a licensing authority. The licensing authority is obliged to issue the duplicate to the applicant no later than in:

Determination of pH of a biological material by means of indicator paper is applied for the preliminary conclusion about substances that might have caused intoxication. The indicator paper moistened with plumbum acetate solution was exposed to the evaporations of the material under examination and turned black. This indicates that the material under examination contains:

Lapkina-Lazarenko method of ethylene glycol separation enables to isolate it effectively from the objects of chemotoxicological analysis. What is the selective transporter of ethylene glycol from the objects to the distillate?

Tincture of what medicinal plant can be applied as a tonic?

Theobromine and theophylline can be determined by alkalimetric method according to the substituent. What acid is to be titrated with sodium hydroxide?

Calculate the quantity of dried belladonna extract (1:2) required for preparing the following drug formulation: Extracti Belladonnae 0,015 Magnesii oxydi 0,5 Natrii hydrocarbonatis 0,2 Misce ut fiat pulvis Da tales doses №10 Signa. 1 powder thrice a day.

A 25-year-old patient has been taking antibiotics for 7 days. Antibiotic therapy has caused a complication in form of bowel dysbacteriosis. This complication should be treated with drugs of the following pharmacological group:

A 57-year-old female patient was diagnosed with rheumatoid arthritis; she has also a history of stomach ulcer. What drug from the group of nonsteroid antiinflammatory drugs may be recommended this patient?

Aerosol department of a pharmaceutical factory uses condensed gases in the capacity of propellants. Which of the following substances relates to the group of condensed gases?

An internship doctor prescribed his patient nifuroxazid from the group of ni-trofurans for treatment of urinary tracts infection. The doctor made a mistake because: